钾通道亚家族K成员17 (2P结构域钾通道Talk-2) (酸敏感性钾通道蛋白TASK-4) (TWIK相关酸敏感性K(+)通道4) (TWIK相关碱性pH激活K(+)通道2) (TALK-2)
钾通道亚家族K成员17 (2P结构域钾通道Talk-2) (酸敏感性钾通道蛋白TASK-4) (TWIK相关酸敏感性K(+)通道4) (TWIK相关碱性pH激活K(+)通道2) (TALK-2)
Q96T54功能描述
K(+)通道，在膜去极化时传导电压依赖性外向整流电流。电压感测以一种“离子流门控”模式与K(+)电化学梯度耦合，其中外向而非内向离子流打开通道门 (PubMed:11248242, PubMed:11263999, PubMed:26919430, PubMed:36063992)。同源和异源二聚化形成具有独特调节和门控特性的功能性通道 (PubMed:36063992)。存在于心脏传导系统中，可能调节心肌细胞的动作电位时程和搏动频率 (PubMed:24972929)。对其他单价阳离子如Rb(+)和Cs(+)具有通透性 (By similarity) (PubMed:26919430)。 {ECO:0000250|UniProtKB:Q96T55, ECO:0000269|PubMed:11248242, ECO:0000269|PubMed:11263999, ECO:0000269|PubMed:24972929, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992}。
组织特异性
Widely expressed. Highly expressed in aorta and coronary artery. Expressed in pancreas, in both endocrine (alpha, beta, gamma, delta, and epsilon) and exocrine (acinar and ductal) cells.
亚细胞定位
Cell membrane
关键词