A型钾通道调节蛋白KCNIP2 (心脏电压门控钾通道调节亚基) (Kv通道相互作用蛋白2) (KChIP2) (钾通道相互作用蛋白2)
A型钾通道调节蛋白KCNIP2 (心脏电压门控钾通道调节亚基) (Kv通道相互作用蛋白2) (KChIP2) (钾通道相互作用蛋白2)
Q9NS61功能描述
Kv4/D (Shal)型电压门控快速失活A型钾通道的调节亚基 (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220)。以钙依赖性和亚型特异性方式调节通道密度、失活动力学及失活恢复速率 (PubMed:10676964, PubMed:11287421, PubMed:11684073, PubMed:12297301, PubMed:14623880, PubMed:34997220)。参与KCND2和KCND3向细胞表面的转运 (PubMed:12829703)。可能为心脏I(To)电流的表达所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q9JJ69, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11287421, ECO:0000269|PubMed:11684073, ECO:0000269|PubMed:12297301, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:34997220}。
组织特异性
Expressed in brain. Colocalizes with KCND2 in excitatory neurons including cortical and hippocampal CA1 pyramidal cells. Isoform 3 is expressed in heart and in umbilical vein endothelial cells. Not expressed in fetal heart.
亚细胞定位
[Isoform 1]: Cell membrane
关键词