A型钾通道调节蛋白KCNIP1 (Kv通道相互作用蛋白1) (KChIP1) (钾通道相互作用蛋白1) (囊泡APC结合蛋白)
A型钾通道调节蛋白KCNIP1 (Kv通道相互作用蛋白1) (KChIP1) (钾通道相互作用蛋白1) (囊泡APC结合蛋白)
Q9NZI2功能描述
Kv4/D (Shal)型电压门控快速失活A型钾通道的调节亚基 (PubMed:10676964, PubMed:11423117, PubMed:17187064, PubMed:34552243, PubMed:34997220)。以钙依赖性和亚型特异性的方式调节通道密度、失活动力学以及失活恢复速率 (PubMed:10676964, PubMed:11423117, PubMed:17187064, PubMed:34552243, PubMed:34997220)。在体外，调节KCND1/Kv4.1和KCND2/Kv4.2电流 (PubMed:34552243)。增加KCND2在细胞表面的存在 (PubMed:12829703)。 {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:17187064, ECO:0000269|PubMed:34552243, ECO:0000269|PubMed:34997220}。
组织特异性
Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.
亚细胞定位
Cell membrane
关键词