KCNAB1 Q14722

电压门控钾通道β1亚基 (EC 1.1.1.-) (K(+)通道β1亚基) (Kv-beta-1)

功能描述

电压门控钾 (Kv) Shaker通道的调节亚基，由成孔和传导钾离子的α亚基及调节β亚基组成 (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988)。β-1/KCNAB1胞质亚基通过其N末端结构域物理阻塞孔道，介导延迟整流钾通道的关闭，并加快其他家族成员的通道关闭速度 (PubMed:9763623)。促进含有Kv1.1/KCNA1、Kv1.2/KCNA2、Kv1.4/KCNA4、Kv1.5/KCNA5和Kv1.6/KCNA6 α亚基的通道失活 (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623)。通过催化多种内源性醛和酮的NADPH依赖性还原，显示烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 依赖性的醛酮还原酶活性 (By similarity)。NADPH的结合是有效下调钾通道活性所必需的 (PubMed:17540341)。结合的NADPH的氧化限制了N末端结构域对通道的阻塞，从而降低了钾通道活性的N型失活 (By similarity)。 {ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:9763623}.; FUNCTION: [Isoform KvB1.2]: Isoform KvB1.2对KCNA1、KCNA2或KCNB1无影响。 {ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764}.

组织特异性

In brain, expression is most prominent in caudate nucleus, hippocampus and thalamus. Significant expression also detected in amygdala and subthalamic nucleus. Also expressed in both healthy and cardiomyopathic heart. Up to four times more abundant in left ventricle than left atrium.

亚细胞定位

Cytoplasm