Janus激酶和微管相互作用蛋白1 (GABA-B受体结合蛋白) (多α螺旋和RNA连接蛋白1) (Marlin-1)
Janus激酶和微管相互作用蛋白1 (GABA-B受体结合蛋白) (多α螺旋和RNA连接蛋白1) (Marlin-1)
Q96N16功能描述
与微管结合，可能在GABA-B受体的微管依赖性转运中发挥作用。可能在JAK1信号传导中发挥作用并调节微管细胞骨架重排。 {ECO:0000269|PubMed:14718537, ECO:0000269|PubMed:15277531, ECO:0000269|PubMed:17532644}.
组织特异性
Predominantly expressed in neural tissues and lymphoid cells (at protein level). Isoform 2, isoform 3 and isoform 4 are specifically expressed in brain and retina. Isoform 1 and isoform 5 are also detected in liver, lung and skeletal muscle. Also detected in testis and to a lower extent spleen and intestine.
亚细胞定位
Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Colocalizes with the microtubule network. Localizes to the cell body and neurites of hippocampal neurons where it accumulates in granules. Localizes to the tail and to a lower extent to the head of sperm cells.
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