酪氨酸蛋白激酶JAK1 (EC 2.7.10.2) (Janus激酶1) (JAK-1)
酪氨酸蛋白激酶JAK1 (EC 2.7.10.2) (Janus激酶1) (JAK-1)
P23458功能描述
非受体型酪氨酸激酶，参与IFN-alpha/beta/gamma信号通路 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552)。白细胞介素 (IL)-2受体 (PubMed:11909529) 以及白细胞介素 (IL)-10受体 (PubMed:12133952) 的激酶搭档。I型干扰素受体IFNAR2的激酶搭档 (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552)。响应干扰素与IFNAR1-IFNAR2异源二聚体的结合，磷酸化并激活其结合搭档IFNAR2，为STAT蛋白创建停泊位点 (PubMed:7759950)。直接磷酸化STAT蛋白，但也通过反式激活与信号受体相关的其他JAK激酶来激活STAT信号传导 (PubMed:16239216, PubMed:32750333, PubMed:8232552)。 {ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12133952, ECO:0000269|PubMed:16239216, ECO:0000269|PubMed:28111307, ECO:0000269|PubMed:32750333, ECO:0000269|PubMed:7615558, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:8232552}。
组织特异性
Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
亚细胞定位
Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
关键词