ITPKC Q96DU7

肌醇三磷酸3-激酶C (EC 2.7.1.127) (肌醇1,4,5-三磷酸3-激酶C) (IP3 3-激酶C) (IP3K C) (InsP 3-激酶C)

蛋白质信息 (UniProt)

肌醇三磷酸3-激酶C (EC 2.7.1.127) (肌醇1,4,5-三磷酸3-激酶C) (IP3 3-激酶C) (IP3K C) (InsP 3-激酶C)

Q96DU7

功能描述

催化1D-myo-inositol 1,4,5-trisphosphate (InsP3)磷酸化为1D-myo-inositol 1,3,4,5-tetrakisphosphate，并参与钙稳态的调节 (PubMed:11085927, PubMed:12747803)。可将inositol 2,4,5-triphosphate磷酸化为inositol 2,4,5,6-tetraphosphate (By similarity)。 {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}。

组织特异性

Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain.

亚细胞定位

Nucleus

关键词

3D-structure ATP-binding Calmodulin-binding Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q96DU7

NCBI Gene

GeneCards