ITLN1 Q8WWA0

肠lectin-1 (ITLN-1) (内皮lectin HL-1) (半乳呋喃糖结合lectin) (肠乳铁蛋白受体) (网膜素)

功能描述

一种以钙依赖性方式特异性识别微生物碳水化合物链的凝集素 (PubMed:11313366, PubMed:26148048)。与含有末端无环1,2-二醇部分的微生物聚糖结合，包括β-连接的D-半乳呋喃糖 (beta-Galf)、D-磷酸甘油修饰的聚糖、D-甘油-D-塔洛-辛-2-酮糖酸 (KO) 和3-脱氧-D-甘露-辛-2-酮糖酸 (KDO) (PubMed:26148048)。与革兰氏阳性和革兰氏阴性细菌（包括肺炎克雷伯菌、肺炎链球菌、鼠疫耶尔森菌、奇异变形杆菌和普通变形杆菌）的聚糖结合 (PubMed:26148048)。不结合人类聚糖 (PubMed:26148048)。可能在针对微生物的防御系统中发挥作用 (Probable)。可能作为脂肪因子发挥作用，对基础葡萄糖摄取无影响，但能增强脂肪细胞中胰岛素刺激的葡萄糖摄取 (PubMed:16531507)。在胰岛素存在和不存在的情况下均增加AKT磷酸化 (PubMed:16531507)。可能与乳铁蛋白/LTF相互作用并增加其摄取，从而可能在铁吸收中发挥作用 (PubMed:11747454, PubMed:23921499)。 {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000269|PubMed:23921499, ECO:0000269|PubMed:26148048, ECO:0000305, ECO:0000305|PubMed:11747454}。

组织特异性

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level) (PubMed:16531507). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus.

亚细胞定位

Cell membrane