ITGA7 Q13683

整合素α-7 [切割为：整合素α-7重链；整合素α-7轻链；整合素α-7 70 kDa形式]

功能描述

整联蛋白alpha-7/beta-1是骨骼肌成肌细胞和成年肌纤维上的主要层粘连蛋白受体。在肌源性分化过程中，它可能诱导成肌细胞形状和运动性的改变，并促进其在次级纤维形成富含层粘连蛋白位点的定位。它参与肌纤维细胞结构的维持以及它们的锚定、存活和功能完整性。Isoform Alpha-7X2B和isoform Alpha-7X1B促进成肌细胞在层粘连蛋白1和层粘连蛋白2/4上的迁移，但isoform Alpha-7X1B在层粘连蛋白1上的活性较低(In vitro)。作为施万细胞层粘连蛋白-2的受体。作为COMP的受体并介导其对血管平滑肌细胞(VSMCs)成熟的影响(By similarity)。在分化的气道平滑肌(ASM)细胞中促进收缩表型的获得。 {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}。

组织特异性

Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes. Isoforms containing segment X2D are expressed at low levels in fetal and adult skeletal muscle and in cardiac muscle, but are not detected in myoblasts and myotubes. In muscle fibers isoforms containing segment A and B are expressed at myotendinous and neuromuscular junctions; isoforms containing segment C are expressed at neuromuscular junctions and at extrasynaptic sites. Isoforms containing segments X1 or X2 or, at low levels, X1X2 are expressed in fetal and adult skeletal muscle (myoblasts and myotubes) and cardiac muscle.

亚细胞定位

Membrane; Single-pass type I membrane protein.