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ITGA3 P26006

整合素α-3 (CD49抗原样家族成员C) (FRP-2) (半乳糖蛋白B3) (GAPB3) (VLA-3亚基α) (CD抗原CD49c) [切割为:整合素α-3重链;整合素α-3轻链]

蛋白质信息 (UniProt)

整合素α-3 (CD49抗原样家族成员C) (FRP-2) (半乳糖蛋白B3) (GAPB3) (VLA-3亚基α) (CD抗原CD49c) [切割为:整合素α-3重链;整合素α-3轻链]

P26006

功能描述

整合素alpha-3/beta-1是纤连蛋白、层粘连蛋白、胶原蛋白、epiligrin、血小板反应蛋白和CSPG4的受体。整合素alpha-3/beta-1以胶原蛋白依赖的方式在侵袭伪足质膜处为FAP (seprase) 提供停靠位点,因此可能参与粘附、侵袭伪足形成和基质降解过程,促进细胞侵袭。Alpha-3/beta-1可能与LGALS3一起介导CSPG4对内皮细胞迁移的刺激作用。 {ECO:0000269|PubMed:10455171, ECO:0000269|PubMed:15181153}.; FUNCTION: (微生物感染) 整合素ITGA3:ITGB1可能作为少根根霉(R.delemar)CotH7在肺泡上皮细胞中的受体,这可能是肺毛霉菌病病程进展的早期步骤。 {ECO:0000269|PubMed:32487760}.

组织特异性

Isoform 1 is widely expressed. Isoform 2 is expressed in brain and heart. In brain, both isoforms are exclusively expressed on vascular smooth muscle cells, whereas in heart isoform 1 is strongly expressed on vascular smooth muscle cells, isoform 2 is detected only on endothelial vein cells.

亚细胞定位

Cell membrane

关键词

Alternative splicing Calcium Cell adhesion Cell junction Cell membrane Cell projection Cleavage on pair of basic residues Direct protein sequencing Disease variant Disulfide bond