ITGA2B P08514

整合素 α-IIb (GPalpha IIb) (GPIIb) (血小板膜糖蛋白 IIb) (CD抗原 CD41) [裂解为：整合素 α-IIb 重链；整合素 α-IIb 轻链，形式1；整合素 α-IIb 轻链，形式2]

功能描述

整合素alpha-IIb/beta-3 (ITGA2B:ITGB3) 是纤连蛋白、纤维蛋白原、纤溶酶原、凝血酶原、血小板反应蛋白和玻璃体结合蛋白的受体。它识别广泛配体中的R-G-D序列。它识别纤维蛋白原gamma链中的序列H-H-L-G-G-G-A-K-Q-A-G-D-V (By similarity)。激活后，整合素alpha-IIb/beta-3通过结合可溶性纤维蛋白原介导血小板/血小板相互作用 (PubMed:9111081)。该步骤导致快速血小板聚集，从而物理性封闭破裂的内皮细胞表面 (By similarity)。整合素ITGA2B:ITGB3也是红细胞特异性ICAM4配体的受体，参与红细胞与活化血小板之间的异型细胞-细胞粘附 (PubMed:12477717)。 {ECO:0000250|UniProtKB:O54890, ECO:0000269|PubMed:12477717, ECO:0000269|PubMed:9111081}。

组织特异性

Isoform 1 and isoform 2 are expressed in platelets and megakaryocytes, but not in reticulocytes. Not detected in Jurkat, nor in U937 cell lines (PubMed:2351656). Isoform 3 is expressed in prostate adenocarcinoma, as well as in several erythroleukemia, prostate adenocarcinoma and melanoma cell lines, including PC-3, DU-145, HEL, WM983A, WM983B and WM35. Not detected in platelets, nor in normal prostate (at protein level) (PubMed:9809974).

亚细胞定位

Cell membrane