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ING2 Q9H160

生长抑制蛋白2 (生长抑制1样蛋白) (ING1Lp) (p32) (p33ING2)

蛋白质信息 (UniProt)

生长抑制蛋白2 (生长抑制1样蛋白) (ING1Lp) (p32) (p33ING2)

Q9H160

功能描述

似乎参与p53/TP53激活和p53/TP53依赖性凋亡途径,可能通过增强p53/TP53的乙酰化。mSin3A样辅阻遏复合物的组分,可能参与核小体组蛋白的去乙酰化。ING2活性似乎受与磷酸肌醇(PtdInsPs)结合的调节。 {ECO:0000269|PubMed:11481424, ECO:0000269|PubMed:12859901}。

组织特异性

Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.

亚细胞定位

Nucleus

关键词

Alternative splicing Chromatin regulator Coiled coil Direct protein sequencing Growth regulation Isopeptide bond Metal-binding Nucleus Proteomics identification Reference proteome