生长抑制蛋白1
生长抑制蛋白1
Q9UK53功能描述
通过调节p53依赖的转录激活，与p53/TP53在细胞生长的负调控通路中协同作用。提示为一种肿瘤抑制基因。 {ECO:0000269|PubMed:9440695}。
组织特异性
Isoform 2 was expressed in all normal tissues and cells examined, as well as in all breast cancer and melanoma cell lines examined. Isoform 3 was expressed in testis, liver, and kidney, weakly expressed in colon and brain and not expressed in breast and cultured melanocytes. Isoform 4 was highly expressed in testis and weakly expressed in brain, but not expressed in breast, colon, kidney, melanocytes, breast cancer or melanoma cell lines.
亚细胞定位
Nucleus
关键词