INCA1 Q0VD86

INCA1蛋白 (与细胞周期蛋白A1相互作用的CDK抑制剂)

功能描述

结合CDK2结合的cyclins并抑制CDK2的激酶活性；结合cyclins对于其作为CDK抑制剂的功能至关重要 (PubMed:21540187)。抑制细胞生长和细胞增殖，可能在细胞周期控制中发挥作用 (By similarity)。为ING5介导的S期进程调控、Fas诱导的细胞凋亡增强和细胞生长抑制所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q6KN7, ECO:0000269|PubMed:21540187}。

组织特异性

Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402). Down-regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187).

亚细胞定位

Nucleus