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IMPG2 Q9BZV3

光感受器间基质蛋白聚糖2 (200 kDa光感受器间基质蛋白聚糖) (IPM 200) (视锥视杆相关唾液蛋白聚糖) (Spacrcan)

蛋白质信息 (UniProt)

光感受器间基质蛋白聚糖2 (200 kDa光感受器间基质蛋白聚糖) (IPM 200) (视锥视杆相关唾液蛋白聚糖) (Spacrcan)

Q9BZV3

功能描述

硫酸软骨素和透明质酸结合蛋白聚糖,参与光感受器间基质的组织;可能参与光敏感光感受器外节的成熟和维持。结合肝素。 {ECO:0000269|PubMed:10702256}。

组织特异性

Expressed in the retina (at protein level) (PubMed:10702256, PubMed:29777959). Expressed by photoreceptors of the interphotoreceptor matrix (IPM) surrounding both rods and cones (at protein level) (PubMed:10542133, PubMed:29777959). IPM occupies the subretinal space between the apices of the retinal pigment epithelium and the neural retina (PubMed:10542133). Expressed in the pineal gland (at protein level) (PubMed:10702256).

亚细胞定位

Photoreceptor outer segment membrane

关键词

Cell projection Direct protein sequencing Disease variant Disulfide bond EGF-like domain Extracellular matrix Glycoprotein Heparin-binding Membrane Proteomics identification