白细胞介素-37 (IL-37) (FIL1 zeta) (IL-1X) (白细胞介素-1家族成员7) (IL-1F7) (白细胞介素-1同源物4) (IL-1H) (IL-1H4) (白细胞介素-1 zeta) (IL-1 zeta) (白细胞介素-1相关蛋白) (IL-1RP1)
白细胞介素-37 (IL-37) (FIL1 zeta) (IL-1X) (白细胞介素-1家族成员7) (IL-1F7) (白细胞介素-1同源物4) (IL-1H) (IL-1H4) (白细胞介素-1 zeta) (IL-1 zeta) (白细胞介素-1相关蛋白) (IL-1RP1)
Q9NZH6功能描述
免疫调节细胞因子，作为先天炎症和免疫反应的抑制因子，参与遏制过度炎症。信号传导可通过两种机制发生：细胞内通过与SMAD3核易位，以及细胞外分泌后结合由IL18R1和IL18RAP组成的受体。抑制或减少促炎细胞因子的产生，包括IL1A和IL6，以及CCL12、CSF1、CSF2、CXCL13、IL1B、IL23A和IL1RN，但保留抗炎细胞因子。抑制树突状细胞活化。 {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}。
组织特异性
In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
亚细胞定位
Cytoplasm, cytosol
关键词