IL27RA Q6UWB1

白细胞介素-27受体亚基α (IL-27受体亚基alpha) (IL-27R亚基alpha) (IL-27R-alpha) (IL-27RA) (细胞因子受体WSX-1) (细胞因子受体样1) (I型T细胞细胞因子受体) (TCCR) (ZcytoR1)

功能描述

IL27的受体。需要IL6ST/GP130介导针对IL27的信号转导。该信号系统通过STAT3和STAT1起作用。作为与IL6ST/GP130和CNTFR形成的复合物的一部分，充当神经保护肽humanin的受体 (PubMed:19386761)。参与Th1型免疫反应的调节。似乎也参与先天防御机制。 {ECO:0000269|PubMed:14764690, ECO:0000269|PubMed:19386761}。

组织特异性

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, small intestine, kidney and colon. In the lymphoid system, higher level expression in CD4+ T-cell subsets than in CD8+ T-cell subsets. Also weaker expression in CD19+ B-cells and monocytes.

亚细胞定位

Membrane; Single-pass type I membrane protein.