白细胞介素-1受体辅助蛋白 (IL-1受体辅助蛋白) (IL-1RAcP) (EC 3.2.2.6) (白细胞介素-1受体3) (IL-1R-3) (IL-1R3)
白细胞介素-1受体辅助蛋白 (IL-1受体辅助蛋白) (IL-1RAcP) (EC 3.2.2.6) (白细胞介素-1受体3) (IL-1R-3) (IL-1R3)
Q9NPH3功能描述
IL-36信号系统中的IL1RL2共受体 (By similarity)。IL-1信号系统中与IL1R1结合的共受体。与结合了IL1B的IL1R1结合形成高亲和力白细胞介素-1受体复合物，该复合物介导白细胞介素-1依赖性的NF-kappa-B及其他通路的激活。信号传导涉及通过受体/共受体亚基各自的TIR结构域招募适配分子，如TOLLIP、MYD88和IRAK1或IRAK2。招募TOLLIP至信号复合物。不单独结合白细胞介素-1；IL1RN与IL1R1结合，阻止其与IL1R1结合形成信号复合物。细胞反应通过与膜IL1R2诱饵受体的非信号传导结合进行调节。IL-33信号系统中的IL1RL1共受体。可通过跨突触结合PTPRD双向诱导神经元的突触前和突触后分化 (By similarity)。可能在IL1B介导的T辅助细胞1 (Th1) 产生IFNG的共刺激中发挥作用 (Probable)。 {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:10799889, ECO:0000269|PubMed:9371760, ECO:0000305|PubMed:10653850, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform 2]: 与分泌型配体结合的IL1R2结合，并增加分泌型IL1R2对IL1B的亲和力；这种复合物的形成可能是分泌型/可溶性受体中和IL1B的主要机制 (PubMed:12530978)。增强分泌型IL1R1抑制IL-33信号传导的能力 (By similarity)。 {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:12530978}.; FUNCTION: [Isoform 4]: 无法介导经典的IL-1信号传导 (PubMed:19481478)。IL1B诱导Src磷酸化所必需。可能参与IL1B增强的NMDA诱导的神经元钙内流 (By similarity)。 {ECO:0000250|UniProtKB:Q61730, ECO:0000269|PubMed:19481478}.
组织特异性
Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML). Overexpressed in patients with chronic obstructive pulmonary disease (COPD). Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850).
亚细胞定位
[Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.
关键词