白细胞介素-18受体辅助蛋白 (IL-18受体辅助蛋白) (IL-18RAcP) (EC 3.2.2.6) (辅助蛋白样) (AcPL) (CD218抗原样家族成员B) (CDw218b) (IL-1R辅助蛋白样) (IL-1RAcPL) (白细胞介素-1受体7) (IL-1R-7) (IL-1R7) (白细胞介素-18受体辅助蛋白样) (白细胞介素-18受体β) (IL-18R-beta) (IL-18Rbeta) (CD抗原CD218b)
白细胞介素-18受体辅助蛋白 (IL-18受体辅助蛋白) (IL-18RAcP) (EC 3.2.2.6) (辅助蛋白样) (AcPL) (CD218抗原样家族成员B) (CDw218b) (IL-1R辅助蛋白样) (IL-1RAcPL) (白细胞介素-1受体7) (IL-1R-7) (IL-1R7) (白细胞介素-18受体辅助蛋白样) (白细胞介素-18受体β) (IL-18R-beta) (IL-18Rbeta) (CD抗原CD218b)
O95256功能描述
在IL18受体复合物中，不介导IL18结合，但参与IL18依赖的信号转导，导致NF-kappa-B和JNK激活 (PubMed:14528293, PubMed:25500532, PubMed:9792649)。可能在IL18介导的T辅助细胞1 (Th1)合成IFNG中发挥作用 (Probable)。 {ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:9792649, ECO:0000305|PubMed:10653850}。
组织特异性
Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus (PubMed:17897836). Strongly expressed in peripheral blood leukocytes and spleen and, to a lesser extent, in colon (PubMed:9792649). Specifically coexpressed with IL18R1 in T-helper 1 (Th1)cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).
亚细胞定位
Cell membrane
关键词