白细胞介素-17受体D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (白细胞介素-17受体样蛋白) (Sef同源物) (hSef)
白细胞介素-17受体D (IL-17 receptor D) (IL-17RD) (IL17Rhom) (白细胞介素-17受体样蛋白) (Sef同源物) (hSef)
Q8NFM7功能描述
成纤维细胞生长因子介导的Ras-MAPK信号传导和ERK激活的反馈抑制剂 (PubMed:12807873, PubMed:12958313)。通过空间上阻断活化ERK的核易位而不抑制ERK的细胞质磷酸化，来调节核ERK信号通路 (PubMed:15239952)。介导JNK激活，可能参与细胞凋亡 (By similarity)。可能抑制FGF诱导的FGFR1酪氨酸磷酸化 (By similarity)。可能在GnRH分泌神经元的命运决定早期阶段发挥作用 (By similarity)。抑制TGFB诱导的晶状体上皮细胞上皮-间质转化 (By similarity)。 {ECO:0000250|UniProtKB:Q8JZL1, ECO:0000269|PubMed:12807873, ECO:0000269|PubMed:12958313, ECO:0000269|PubMed:15239952}.
组织特异性
Expressed in umbilical vein endothelial cells and in several highly vascularized tissues such as kidney, colon, skeletal muscle, heart and small intestine. Highly expressed in ductal epithelial cells of salivary glands, seminal vesicles and the collecting tubules of the kidney. Isoform 1 is also highly expressed in both fetal and adult brain, pituitary, tonsils, spleen, adenoids, fetal kidney, liver, testes and ovary. Isoform 1 is also expressed at moderate levels in primary aortic endothelial cells and adrenal medulla, and at low levels in adrenal cortex. Isoform 4 is specifically and highly expressed in pituitary, fetal brain and umbilical vein endothelial cells.
亚细胞定位
Golgi apparatus membrane
关键词