Eos锌指蛋白 (Ikaros家族锌指蛋白4)
Eos锌指蛋白 (Ikaros家族锌指蛋白4)
Q9H2S9功能描述
DNA结合蛋白，结合于5'GGGAATRCC-3' Ikaros结合序列。转录抑制因子。与SPI1和MITF相互作用，通过招募共抑制因子SIN3A和CTBP2抑制CTSK和ACP5启动子的转录。可能参与中枢和外周神经系统的发育。对调节性T细胞(Treg)的抑制功能至关重要。通过招募共抑制因子CTBP1介导调节性T细胞(Treg)中FOXP3介导的基因沉默（通过相似性）。 {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}。
组织特异性
Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of myeloid and early megakaryocytic cells respectively.
亚细胞定位
Nucleus
关键词