IFNAR2 P48551

α/β干扰素受体2 (IFN-R-2) (IFN-α结合蛋白) (α/β干扰素受体2) (α干扰素结合蛋白) (I型干扰素受体2)

功能描述

与IFNAR1共同形成I型干扰素（包括干扰素alpha、beta、epsilon、omega和kappa）的异二聚体受体 (PubMed:10049744, PubMed:10556041, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169)。I型干扰素结合激活JAK-STAT信号级联反应，导致编码干扰素反应效应蛋白的干扰素调节基因发生转录激活或抑制 (PubMed:10049744, PubMed:17517919, PubMed:21854986, PubMed:26424569, PubMed:28165510, PubMed:32972995, PubMed:7665574, PubMed:7759950, PubMed:8181059, PubMed:8798579, PubMed:8969169)。机制上，I型干扰素结合使IFNAR1和IFNAR2亚基彼此靠近，驱动其关联的Janus激酶(JAKs)（结合于IFNAR1的TYK2和结合于IFNAR2的JAK1）相互磷酸化 (PubMed:10556041, PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995)。活化的激酶磷酸化IFNAR1和IFNAR2胞内结构域上的特定酪氨酸残基，形成STAT转录因子（STAT1、STAT2和STAT）的停靠位点 (PubMed:11682488, PubMed:12105218, PubMed:21854986, PubMed:32972995)。随后STAT蛋白被JAKs磷酸化，促进其易位至细胞核以调节干扰素调节基因的表达 (PubMed:12105218, PubMed:28165510, PubMed:9121453)。 {ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:17517919, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:28165510, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7759950, ECO:0000269|PubMed:8181059, ECO:0000269|PubMed:8798579, ECO:0000269|PubMed:8969169, ECO:0000269|PubMed:9121453}.; FUNCTION: [Isoform 3]: I型IFN受体活性的强效抑制剂。 {ECO:0000269|PubMed:7759950}.

组织特异性

Isoform 3 is detected in the urine (at protein level) (PubMed:7759950, PubMed:8181059). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines.

亚细胞定位

[Isoform 1]: Cell membrane