吲哚胺2,3-双加氧酶1 (IDO-1) (EC 1.13.11.52) (吲哚胺-吡咯2,3-双加氧酶)
吲哚胺2,3-双加氧酶1 (IDO-1) (EC 1.13.11.52) (吲哚胺-吡咯2,3-双加氧酶)
P14902功能描述
沿犬尿氨酸途径催化必需氨基酸色氨酸分解代谢的第一步及限速步骤 (PubMed:17671174, PubMed:18026683)。参与外周免疫耐受，通过防止由失控和过度反应的免疫反应导致的自身免疫或免疫病理，有助于维持稳态 (PubMed:25691885)。色氨酸缺乏抑制T淋巴细胞分裂，色氨酸代谢产物积累诱导T细胞凋亡和调节性T细胞分化 (PubMed:25691885)。作为抗肿瘤免疫的抑制因子 (PubMed:14502282, PubMed:23103127, PubMed:25157255, PubMed:25691885)。通过剥夺色氨酸限制胞内病原体的生长 (PubMed:25691885)。保护胎儿免受母体免疫排斥 (PubMed:25691885)。 {ECO:0000269|PubMed:14502282, ECO:0000269|PubMed:17671174, ECO:0000269|PubMed:18026683, ECO:0000303|PubMed:23103127, ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}。
组织特异性
Expressed in mature dendritic cells located in lymphoid organs (including lymph nodes, spleen, tonsils, Peyers's patches, the gut lamina propria, and the thymic medulla), in some epithelial cells of the female genital tract, as well as in endothelial cells of term placenta and in lung parenchyma (PubMed:25691885). Weakly or not expressed in most normal tissues, but mostly inducible in most tissues (PubMed:25691885). Expressed in more than 50% of tumors, either by tumoral, stromal, or endothelial cells (expression in tumor is associated with a worse clinical outcome) (PubMed:18418598). Not overexpressed in tumor-draining lymph nodes (PubMed:25691885, PubMed:26155395).
亚细胞定位
Cytoplasm, cytosol
关键词