IBTK Q9P2D0

Bruton酪氨酸激酶抑制剂 (IBtk)

功能描述

作为BTK酪氨酸激酶活性的抑制剂，从而在B细胞发育中发挥作用。下调BTK激酶活性，导致干扰BTK介导的钙动员和NF-kappa-B驱动的转录。 {ECO:0000269|PubMed:11577348}。

组织特异性

Expressed in DeFew, HEK293T, HeLa and in Jurkat, MC3 and NB4 lymphoid cells (at protein level). Isoform 1 is the predominant isoform expressed in all examined tissues and cell lines. Highly expressed in hemopoietic tissues (fetal liver, spleen, lymph node, thymus, peripheral blood leukocytes and bone marrow). Weakly or not expressed in other tissues.

亚细胞定位

Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.