透明质酸酶-1 (Hyal-1) (EC 3.2.1.35) (透明质酸葡萄糖胺酶-1) (肺癌蛋白 1) (LuCa-1)
透明质酸酶-1 (Hyal-1) (EC 3.2.1.35) (透明质酸葡萄糖胺酶-1) (肺癌蛋白 1) (LuCa-1)
Q12794功能描述
可能在促进肿瘤进展中发挥作用。可能阻断TGFB1增强的细胞生长。 {ECO:0000269|PubMed:12084718}。
组织特异性
Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues.
亚细胞定位
Secreted
关键词