HTR2B P41595

5-羟色胺受体2B (5-HT-2B) (5-HT2B) (血清素受体2B)

功能描述

5-羟色胺（血清素）的G蛋白偶联受体 (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600)。也是各种麦角生物碱衍生物和精神活性物质的受体 (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:7926008, PubMed:8078486, PubMed:8143856)。配体结合引起构象变化，通过鸟苷酸结合蛋白（G蛋白）触发信号传导，并调节下游效应器的活性 (PubMed:23519215, PubMed:28129538, PubMed:8078486, PubMed:8143856, PubMed:8882600)。HTR2B与G(q)/G(11) G alpha蛋白偶联并激活磷脂酶C-beta，释放二酰甘油（DAG）和1,4,5-三磷酸肌醇（IP3）第二信使，分别调节磷脂酰肌醇3-激酶的活性并促进细胞内储存库释放Ca(2+)离子 (PubMed:18703043, PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:8078486, PubMed:8143856, PubMed:8882600)。Beta-arrestin家族成员通过G蛋白抑制信号传导并介导替代信号通路的激活 (PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581)。在调节多巴胺和5-羟色胺释放、5-羟色胺摄取以及调节细胞外多巴胺和5-羟色胺水平方面发挥作用，从而影响神经活动。可能在疼痛感知中发挥作用 (By similarity)。在行为调节中发挥作用，包括冲动行为 (PubMed:21179162)。胚胎心肌细胞正常增殖和心脏正常发育所必需 (By similarity)。保护心肌细胞免于凋亡 (By similarity)。在肺动脉对慢性缺氧的适应中发挥作用 (By similarity)。在血管收缩中发挥作用 (By similarity)。成骨细胞正常功能和增殖以及维持正常骨密度所必需 (By similarity)。肠道Cajal间质细胞正常增殖所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q02152, ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.

组织特异性

Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.

亚细胞定位

Cell membrane