HTATIP2 Q9BUP3

HTATIP2蛋白 (30 kDa HIV-1 TAT相互作用蛋白) (HIV-1 TAT相互作用蛋白2)

功能描述

通过阻止延伸因子eEF1A的重新激活来抑制翻译 (By similarity)。也可能通过与核输入底物竞争结合一部分核转运受体来抑制核输入 (PubMed:15282309)。此外还有提议认为其作为氧化还原传感器参与细胞氧化应激监控 (PubMed:18519672)。 {ECO:0000250|UniProtKB:B0BNF8, ECO:0000269|PubMed:15282309, ECO:0000269|PubMed:18519672}.

组织特异性

High levels in liver, lung, skeletal muscle, pancreas and placenta (PubMed:9174052). Moderate levels in heart and kidney (PubMed:9174052). Low levels in brain (PubMed:9174052). Not expressed or low levels in variant small cell lung carcinomas, 33% of hepatocellular carcinomas and neuroblastomas (PubMed:14695192). Levels are reduced in the heart of patients with hypertrophic cardiomyopathy and failing hearts (PubMed:31468715).

亚细胞定位

Cytoplasm