11-β-羟基类固醇脱氢酶1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-氧类固醇还原酶) (EC 1.1.1.201) (皮质类固醇11-β-脱氢酶同工酶1) (短链脱氢酶/还原酶家族26C成员1)
11-β-羟基类固醇脱氢酶1 (11-DH) (11-beta-HSD1) (EC 1.1.1.146) (7-氧类固醇还原酶) (EC 1.1.1.201) (皮质类固醇11-β-脱氢酶同工酶1) (短链脱氢酶/还原酶家族26C成员1)
P28845功能描述
在NADP(H)存在下，控制生物活性glucocorticoids（如cortisone转化为cortisol，以及11-dehydrocorticosterone转化为corticosterone）的可逆转化 (PubMed:10497248, PubMed:12460758, PubMed:14973125, PubMed:15152005, PubMed:15280030, PubMed:17593962, PubMed:21453287, PubMed:27927697, PubMed:30902677)。参与corticosteroid受体介导的抗炎反应，以及代谢和稳态过程 (PubMed:10497248, PubMed:12414862, PubMed:15152005, PubMed:21453287)。在眼房水分泌中起作用，维持眼内环境正常压力 (PubMed:11481269)。在体外具有双向性，在体内主要作为还原酶发挥作用，从而增加活性glucocorticoids的浓度 (PubMed:10497248, PubMed:11481269, PubMed:12414862, PubMed:12460758)。具有广泛的底物特异性，除glucocorticoids外，还接受其他steroid和sterol底物 (PubMed:15095019, PubMed:15152005, PubMed:17593962, PubMed:21453287)。互变7-oxo-和7-hydroxy-neurosteroids，例如7-oxopregnenolone和7beta-hydroxypregnenolone、7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) 和7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one) 等 (PubMed:17593962)。催化主要膳食oxysterol——7-ketocholesterol (7-oxocholesterol) 立体特异性转化为极性更强的7-beta-hydroxycholesterol代谢产物 (PubMed:15095019, PubMed:15152005)。7-oxocholesterol是最重要的oxysterols之一，它参与多种事件，如诱导细胞凋亡、在动脉粥样硬化斑块中积累、脂质过氧化和诱导泡沫细胞形成 (PubMed:15095019)。介导7-oxolithocholate的7-oxo还原，主要生成chenodeoxycholate，少量生成ursodeoxycholate，包括其游离形式及与甘氨酸或牛磺酸结合的形式，提供了glucocorticoid活化与胆汁酸代谢之间的联系 (PubMed:21453287)。在体外催化从7-oxo-25-hydroxycholesterol合成7-beta-25-dihydroxycholesterol，该产物作为G-protein-coupled receptor (GPCR) Epstein-Barr病毒诱导基因2 (EBI2) 的配体，从而可能调节免疫细胞迁移 (PubMed:30902677)。 {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:12460758, ECO:0000269|PubMed:14973125, ECO:0000269|PubMed:15095019, ECO:0000269|PubMed:15152005, ECO:0000269|PubMed:17593962, ECO:0000269|PubMed:21453287, ECO:0000269|PubMed:27927697, ECO:0000269|PubMed:30902677, ECO:0000303|PubMed:10497248, ECO:0000303|PubMed:11481269, ECO:0000303|PubMed:12414862, ECO:0000303|PubMed:12460758, ECO:0000303|PubMed:15095019, ECO:0000303|PubMed:15152005, ECO:0000303|PubMed:21453287}.
组织特异性
Widely expressed, highest expression in liver, lower in testis, ovary, lung, foreskin fibroblasts, and much lower in kidney (PubMed:1885595). Expressed in liver (at protein level) (PubMed:21453287). Expressed in the basal cells of the corneal epithelium and in the ciliary nonpigmented epithelium (both at mRNA and at protein level) (PubMed:11481269).
亚细胞定位
Endoplasmic reticulum membrane
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