HRH4 Q9H3N8

组胺H4受体 (H4R) (HH4R) (AXOR35) (G蛋白偶联受体105) (GPRv53) (Pfi-013) (SP9144)

功能描述

G protein-coupled receptor主要表达于免疫细胞，如肥大细胞、嗜酸性粒细胞、嗜碱性粒细胞、树突状细胞和嗜中性粒细胞，在免疫和炎症反应中发挥关键作用 (PubMed:26948974)。通过响应组蛋白介导免疫细胞向炎症或损伤部位的趋化作用 (PubMed:26948974)。组蛋白的激活还影响促炎细胞因子的释放，如TNF、CCL4、IL6和IFN-gamma (PubMed:29600327, PubMed:31583075)。配体结合诱导构象变化，通过G(i)/GNAI1触发信号传导，导致抑制腺苷酸环化酶活性从而降低细胞内cAMP水平 (PubMed:39333117)。此外，在控制肾脏重吸收过程，特别是白蛋白摄取中发挥作用 (By similarity)。 {ECO:0000250|UniProtKB:Q91ZY2, ECO:0000269|PubMed:12503632, ECO:0000269|PubMed:26948974, ECO:0000269|PubMed:29600327, ECO:0000269|PubMed:31583075, ECO:0000269|PubMed:39333117}。

组织特异性

Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils and basophils (PubMed:12503632, PubMed:26948974, PubMed:29600327). Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, testis, colon, fetal liver and lymph node.

亚细胞定位

Cell membrane