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HPR P00739

触珠蛋白相关蛋白

蛋白质信息 (UniProt)

触珠蛋白相关蛋白

P00739

功能描述

灵长类特异性血浆蛋白,与含有载脂蛋白L-I (apoL-I)的高密度脂蛋白 (HDL) 相关。这种HDL颗粒称为锥虫裂解因子-1 (TLF-1),介导人体针对多种非洲锥虫的先天免疫保护。以高亲和力结合血红蛋白,可能有助于清除无细胞血红蛋白,从而允许肝脏对血红素铁的再利用。 {ECO:0000269|PubMed:16778136}。

组织特异性

In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.

亚细胞定位

Secreted

关键词

Alternative splicing Disulfide bond Hemoglobin-binding Proteomics identification Reference proteome Secreted Serine protease homolog Signal Sushi