羟甲基戊二酰辅酶A合酶，线粒体 (HMG-CoA合酶) (EC 2.3.3.10) (3-羟基-3-甲基戊二酰辅酶A合酶)
羟甲基戊二酰辅酶A合酶，线粒体 (HMG-CoA合酶) (EC 2.3.3.10) (3-羟基-3-甲基戊二酰辅酶A合酶)
P54868功能描述
催化生酮作用的第一步不可逆反应，将乙酰-CoA缩合为乙酰乙酰-CoA以形成HMG-CoA，后者被HMG-CoA还原酶 (HMGCR) 转化为甲羟戊酸。 {ECO:0000269|PubMed:11228257, ECO:0000269|PubMed:23751782, ECO:0000269|PubMed:29597274}.
组织特异性
Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle (PubMed:16940161, PubMed:21952825, PubMed:7893153). Not detected in brain (PubMed:21952825).
亚细胞定位
Mitochondrion
关键词