HMGCR P04035

3-羟基-3-甲基戊二酰辅酶A还原酶 (HMG-CoA还原酶) (EC 1.1.1.34)

蛋白质信息 (UniProt)

3-羟基-3-甲基戊二酰辅酶A还原酶 (HMG-CoA还原酶) (EC 1.1.1.34)

P04035

功能描述

催化(3S)-羟基-3-甲基戊二酰辅酶A (HMG-CoA)转化为甲羟戊酸，这是胆固醇和其他类异戊二烯合成中的限速步骤，因此在细胞胆固醇稳态中发挥关键作用 (PubMed:21357570, PubMed:2991281, PubMed:36745799, PubMed:6995544)。HMGCR是他汀类药物（一类降胆固醇药物）的主要靶点 (PubMed:11349148, PubMed:18540668, PubMed:36745799)。 {ECO:0000269|PubMed:11349148, ECO:0000269|PubMed:18540668, ECO:0000269|PubMed:21357570, ECO:0000269|PubMed:2991281, ECO:0000269|PubMed:36745799, ECO:0000269|PubMed:6995544}。

组织特异性

[Isoform 1]: Ubiquitously expressed with the highest levels in the cerebellum, fetal brain, testis, skin and adrenal gland.

亚细胞定位

Endoplasmic reticulum membrane

关键词

3D-structure Alternative splicing Cholesterol biosynthesis Cholesterol metabolism Disease variant Endoplasmic reticulum Glycoprotein Isopeptide bond Limb-girdle muscular dystrophy Lipid biosynthesis

外部链接

UniProt: P04035

NCBI Gene

GeneCards