HKDC1 Q2TB90

己糖激酶 HKDC1 (EC 2.7.1.1) (含己糖激酶结构域蛋白 1)

功能描述

催化己糖磷酸化为己糖6-磷酸，尽管与其他己糖激酶相比活性水平很低 (PubMed:30517626)。与其他己糖激酶相比，具有较低的葡萄糖磷酸化活性 (PubMed:30517626)。参与葡萄糖稳态和肝脏脂质积聚。维持妊娠期间全身葡萄糖稳态所必需；然而需要额外的证据来证实这一作用 (By similarity)。 {ECO:0000250|UniProtKB:Q91W97, ECO:0000269|PubMed:30517626}。

组织特异性

Widely expressed (PubMed:27459389, PubMed:29401404). Highly expressed in the brush border, surface epithelium and the myenteric plexus of the small and large intestines; the acinar centrocytes and interlobular ducts of the pancreas; and the alveolar macrophages in the lungs (at protein level) (PubMed:29401404). Present at moderate level in the thyroid follicular epithelium (at protein level) (PubMed:29401404).

亚细胞定位

Cytoplasm