HIF3A Q9Y2N7

缺氧诱导因子3-α (HIF-3-alpha) (HIF3-alpha) (碱性-螺旋-环-螺旋-PAS蛋白MOP7) (E类碱性螺旋-环-螺旋蛋白17) (bHLHe17) (HIF3-alpha-1) (抑制性PAS结构域蛋白) (IPAS) (PAS蛋白成员7) (含PAS结构域蛋白7)

功能描述

在低氧张力的适应性反应中作为转录调节因子。作为低氧诱导基因表达的调节因子 (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422)。在角膜低氧细胞中作为血管生成的抑制剂。在心肺呼吸系统的发育中起作用。可能也参与细胞凋亡 (By similarity)。 {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000269|PubMed:11573933, ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 2]: 削弱转录因子 HIF1A 结合位于低氧诱导靶基因增强子/启动子内的低氧反应元件 (HRE) 的能力，从而抑制 HRE 驱动的转录激活。也抑制低氧诱导的 ARNT 介导的基因表达。 {ECO:0000269|PubMed:11573933}.; FUNCTION: [Isoform 3]: 削弱转录因子 HIF1A 结合位于低氧诱导靶基因增强子/启动子内的低氧反应元件 (HRE) 的能力，从而抑制 HRE 驱动的转录激活。 {ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 4]: 削弱转录因子 HIF1A 和 EPAS1/HIF2A 结合位于低氧诱导靶基因增强子/启动子内的低氧反应元件 (HRE) 的能力，从而抑制 HRE 驱动的转录激活 (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395)。可能作为肿瘤抑制因子并抑制恶性细胞转化 (PubMed:17998805)。 {ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:17998805, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395}.; FUNCTION: [Isoform 5]: 削弱转录因子 HIF1A 结合位于低氧诱导靶基因增强子/启动子内的低氧反应元件 (HRE) 的能力，从而抑制 HRE 驱动的转录激活。 {ECO:0000269|PubMed:21069422}.

组织特异性

Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells from umbilical cord and aortic endothelial cells) and in vascular smooth muscle cells (aorta) (PubMed:21069422). Strongly expressed in the heart, placenta, and skeletal muscle, whereas a weak expression profile was found in the lung, liver, and kidney (PubMed:12538644). Expressed weakly in cell renal cell carcinoma (CC-RCC) compared to normal renal cells (PubMed:16126907). Expression is down-regulated in numerous kidney tumor cells compared to non tumor kidney tissues (PubMed:16126907). Isoform 2 is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas and in numerous cancer cell lines (PubMed:20416395). Isoform 3 and isoform 4 are weakly expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:20416395). Isoform 4 is expressed in fetal tissues, such as heart, brain, thymus, lung, liver, skeletal kidney and spleen (PubMed:20416395). Isoform 3 is weakly expressed in fetal tissues, such as liver and kidney (PubMed:20416395).

亚细胞定位

Nucleus