HIF1A Q16665

缺氧诱导因子1-α (HIF-1-alpha) (HIF1-alpha) (ARNT相互作用蛋白) (碱性-螺旋-环-螺旋-PAS蛋白MOP1) (E类碱性螺旋-环-螺旋蛋白78) (bHLHe78) (PAS蛋白成员1) (含PAS结构域蛋白8)

功能描述

作为低氧适应反应的主要转录调节因子发挥作用 (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:18658046, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100)。在低氧条件下，激活超过40个基因的转录，包括促红细胞生成素、葡萄糖转运蛋白、糖酵解酶、血管内皮生长因子、HILPDA以及其他基因，这些基因的蛋白产物增加氧气输送或促进对低氧的代谢适应 (PubMed:11292861, PubMed:11566883, PubMed:15465032, PubMed:16973622, PubMed:17610843, PubMed:20624928, PubMed:22009797, PubMed:30125331, PubMed:9887100)。在胚胎血管生成、肿瘤血管生成和缺血性疾病的病理生理学中起重要作用 (PubMed:22009797)。与ARNT异二聚化；异二聚体结合于靶基因启动子低氧反应元件 (HRE) 内的核心DNA序列 5'-TACGTG-3' (By similarity)。激活需要招募转录共激活因子，如CREBBP和EP300 (PubMed:16543236, PubMed:9887100)。与NCOA1和/或NCOA2相互作用可增强活性 (PubMed:10594042)。与氧化还原调节蛋白APEX1相互作用似乎能激活CTAD并增强NCOA1和CREBBP的激活作用 (PubMed:10202154, PubMed:10594042)。参与低氧期间神经元中线粒体的轴突分布和运输 (PubMed:19528298)。 {ECO:0000250|UniProtKB:Q61221, ECO:0000269|PubMed:10202154, ECO:0000269|PubMed:10594042, ECO:0000269|PubMed:11292861, ECO:0000269|PubMed:11566883, ECO:0000269|PubMed:15465032, ECO:0000269|PubMed:16543236, ECO:0000269|PubMed:16973622, ECO:0000269|PubMed:17610843, ECO:0000269|PubMed:18658046, ECO:0000269|PubMed:19528298, ECO:0000269|PubMed:20624928, ECO:0000269|PubMed:22009797, ECO:0000269|PubMed:30125331, ECO:0000269|PubMed:9887100}.; FUNCTION: (Microbial infection) 在感染人冠状病毒SARS-CoV-2后，是单核细胞中糖酵解诱导及随之而来的促炎状态所必需的 (PubMed:32697943)。在单核细胞中，诱导ACE2以及细胞因子（如IL1B、TNF、IL6和干扰素）的表达 (PubMed:32697943)。促进人冠状病毒SARS-CoV-2复制和单核细胞炎症反应 (PubMed:32697943)。 {ECO:0000269|PubMed:32697943}.

组织特异性

Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors. A higher level expression seen in pituitary tumors as compared to the pituitary gland.

亚细胞定位

Cytoplasm