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HHAT Q5VTY9

蛋白质-半胱氨酸 N-棕榈酰转移酶 HHAT (EC 2.3.1.-) (Hedgehog 酰基转移酶) (T细胞识别的黑色素瘤抗原 2) (MART-2) (Skinny hedgehog 蛋白 1)

蛋白质信息 (UniProt)

蛋白质-半胱氨酸 N-棕榈酰转移酶 HHAT (EC 2.3.1.-) (Hedgehog 酰基转移酶) (T细胞识别的黑色素瘤抗原 2) (MART-2) (Skinny hedgehog 蛋白 1)

Q5VTY9

功能描述

棕榈酰酰基转移酶,催化SHH的N端棕榈酰化;这是SHH信号传导所必需的 (PubMed:18534984, PubMed:24784881, PubMed:31875564)。它也催化DHH的N端棕榈酰化 (PubMed:24784881)。促进棕榈酰辅酶A从内质网膜的细胞质侧转移到腔侧,SHH棕榈酰化发生在该处 (PubMed:31875564)。它是胚胎正常发育和睾丸器官发生所必需的因子 (PubMed:24784881)。 {ECO:0000269|PubMed:11486055, ECO:0000269|PubMed:18534984, ECO:0000269|PubMed:24784881, ECO:0000269|PubMed:31875564}。

组织特异性

Widely expressed. Expressed in fetal ovary and testis, with high levels of expression observed in Sertoli cells (PubMed:24784881).

亚细胞定位

Endoplasmic reticulum membrane

关键词

3D-structure Acyltransferase Alternative splicing Developmental protein Disease variant Dwarfism Endoplasmic reticulum Golgi apparatus GTP-binding Lipoprotein