HDAC4 P56524

组蛋白去乙酰化酶4 (HD4) (EC 3.5.1.98)

功能描述

负责核心组蛋白（H2A、H2B、H3和H4）N末端赖氨酸残基的去乙酰化。组蛋白去乙酰化为表观遗传抑制提供了标记，并在转录调节、细胞周期进程和发育事件中起重要作用。组蛋白去乙酰化酶通过形成大型多蛋白复合物发挥作用。通过与肌细胞增强因子如MEF2A、MEF2C和MEF2D相互作用参与肌肉成熟。参与乳腺癌中MTA1介导的ESR1表达表观遗传调节。在'Lys-77'位去乙酰化HSPA1A和HSPA1B，导致其优先结合辅伴侣STUB1 (PubMed:27708256)。 {ECO:0000269|PubMed:10523670, ECO:0000269|PubMed:24413532, ECO:0000269|PubMed:27708256}。

组织特异性

Ubiquitous.

亚细胞定位

Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation. Interaction with SIK3 leads to HDAC4 retention in the cytoplasm (By similarity).