丝氨酸/苏氨酸蛋白激酶haspin (EC 2.7.11.1) (生殖细胞特异性基因2蛋白) (H-haspin) (单倍体生殖细胞特异性核蛋白激酶)
丝氨酸/苏氨酸蛋白激酶haspin (EC 2.7.11.1) (生殖细胞特异性基因2蛋白) (H-haspin) (单倍体生殖细胞特异性核蛋白激酶)
Q8TF76功能描述
丝氨酸/苏氨酸蛋白激酶，在有丝分裂期间磷酸化组蛋白H3的'Thr-3' (H3T3ph)。可能通过H3T3ph定位并调节AURKB及染色体乘客复合体(CPC)其他成分在着丝粒的激活，以确保正确的染色单体凝聚、中期排列以及正常的细胞周期进程。 {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}。
组织特异性
Strongly expressed in testis. Also present in thymus and bone marrow and low levels observed in prostate, intestine, lung, spleen and lymph node. Expressed in fetal skin, liver, kidney and small intestine and also in proliferating but not non-proliferating cell lines.
亚细胞定位
Nucleus
关键词