HABP4 Q5JVS0

胞内透明质酸结合蛋白4 (IHABP-4) (IHABP4) (透明质酸结合蛋白4) (Ki-1/57胞内抗原)

功能描述

一种促进核糖体休眠的核糖体结合蛋白，该过程中核糖体被稳定在非活性状态并免受蛋白酶体降解 (By similarity)。通过在核糖体A位与EEF2/eEF2因子结合发挥作用，促进核糖体稳定在一种适合储存的非活性状态 (By similarity)。通过促进核糖体稳定，在成熟卵母细胞的核糖体休眠中发挥关键作用 (By similarity)。在卵子发生过程中产生的大量核糖体，在卵母细胞和早期胚胎中被储存并受到翻译抑制 (By similarity)。也能结合RNA，调节转录和前mRNA剪接 (PubMed:14699138, PubMed:16455055, PubMed:19523114, PubMed:21771594)。结合（通过C末端）poly(U) RNA (PubMed:19523114)。似乎在PML核体的形成中起作用 (PubMed:28695742)。在心肌细胞中响应机械应力，负向调节转录因子MEF2C的DNA结合活性 (By similarity)。 {ECO:0000250|UniProtKB:A1L1K8, ECO:0000250|UniProtKB:Q5XJA5, ECO:0000269|PubMed:14699138, ECO:0000269|PubMed:16455055, ECO:0000269|PubMed:19523114, ECO:0000269|PubMed:21771594, ECO:0000269|PubMed:28695742}。

组织特异性

Highly expressed in brain, heart, and kidney, and moderately expressed in skeletal muscle. Also expressed in a variety of tumor cell lines and in activated but not resting leukocytes.

亚细胞定位

Nucleus