GSDMC Q9BYG8

Gasdermin-C (黑色素瘤来源的含亮氨酸拉链核外因子) [酶切产生：Gasdermin-C，N端 (GSDMC-NT)；Gasdermin-C，C端 (GSDMC-CT)]

功能描述

[Gasdermin-C]: 该形式构成孔形成蛋白的前体：经切割后，释放的N端部分（Gasdermin-C, N-terminal）结合膜并形成孔，引发细胞焦亡。 {ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.; FUNCTION: [Gasdermin-C, N-terminal]: 导致膜通透化和细胞焦亡的孔形成蛋白 (PubMed:27281216, PubMed:32929201, PubMed:34012073)。由caspase CASP8响应死亡信号切割gasdermin-C产生 (PubMed:32929201, PubMed:34012073)。切割后，转移至质膜，在此与膜内叶脂质强力结合 (PubMed:32929201, PubMed:34012073)。在膜内同源寡聚化并形成内径10-15纳米 (nm) 的孔，引发细胞焦亡 (PubMed:32929201, PubMed:34012073)。 {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.

组织特异性

Expressed mainly in trachea and spleen (PubMed:11223543). In the esophagus, expressed in differentiating cells and probably in differentiated cells. Also detected in gastric epithelium (PubMed:19051310).

亚细胞定位

[Gasdermin-C]: Cytoplasm, cytosol