GSDMA Q96QA5

Gasdermin-A (Gasdermin-1) [切割为：Gasdermin-A，N端 (GSDMA-NT)；Gasdermin-A，C端 (GSDMA-CT)]

功能描述

[Gasdermin-A]: 该形式构成孔形成蛋白的前体，并作为感染传感器：在化脓性链球菌（S.pyogenes）感染后，在上皮细胞中被化脓性链球菌效应蛋白SpeB特异性切割，释放出与膜结合并形成孔的N端部分（Gasdermin-A, N-terminal），从而引发细胞焦亡。{ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}.; FUNCTION: [Gasdermin-A, N-terminal]: 导致膜通透化和细胞焦亡的孔形成蛋白 (PubMed:17471240, PubMed:27281216, PubMed:35110732, PubMed:35545676)。在经化脓性链球菌效应蛋白SpeB切割后释放，并结合膜内侧脂质 (PubMed:27281216, PubMed:35110732, PubMed:35545676)。在膜内同源寡聚化，形成内径为10-15纳米 (nm) 的孔，引发细胞焦亡 (PubMed:27281216, PubMed:35110732, PubMed:35545676)。细胞焦亡触发受感染皮肤细胞的清除，剥夺病原体的保护性生态位，同时诱导炎症反应 (PubMed:35110732, PubMed:35545676)。这最终阻止了细菌穿透上皮屏障以及随后的病原体全身扩散 (PubMed:35110732, PubMed:35545676)。结合心磷脂和其他酸性磷脂，如磷脂酰丝氨酸，这些脂质介导其靶向内膜小叶 (PubMed:27281216, PubMed:35110732)。{ECO:0000269|PubMed:17471240, ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:35110732, ECO:0000269|PubMed:35545676}.

组织特异性

Expressed predominantly in the gastrointestinal tract and, at a lower level, in the skin. Also detected in mammary gland. In the gastrointestinal tract, mainly expressed in differentiated cells, including the differentiated cell layer of esophagus and mucus-secreting pit cells of the gastric epithelium. Down-regulated in gastric cancer cells.

亚细胞定位

[Gasdermin-A]: Cytoplasm, perinuclear region