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GRM7 Q14831

代谢型谷氨酸受体7 (mGluR7)

蛋白质信息 (UniProt)

代谢型谷氨酸受体7 (mGluR7)

Q14831

功能描述

由谷氨酸激活的G蛋白偶联受体,在神经元发育过程中通过MAPK-cAMP-PKA信号通路调节轴突生长 (PubMed:33500274)。配体结合引起构象变化,通过鸟苷酸结合蛋白(G蛋白)触发信号传导,并调节下游效应器的活性,例如其抑制的腺苷酸环化酶 (PubMed:9473604)。 {ECO:0000269|PubMed:33500274, ECO:0000269|PubMed:9473604}。

组织特异性

Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4.

亚细胞定位

Cell membrane

关键词

3D-structure Alternative splicing Cardiomyopathy Cell membrane Disease variant Disulfide bond Epilepsy G-protein coupled receptor Glycoprotein Intellectual disability