G蛋白偶联受体激酶4 (EC 2.7.11.16) (G蛋白偶联受体激酶GRK4) (ITI1)
G蛋白偶联受体激酶4 (EC 2.7.11.16) (G蛋白偶联受体激酶GRK4) (ITI1)
P32298功能描述
特异性磷酸化G蛋白偶联受体的活化形式。GRK4-alpha可磷酸化视紫红质，其活性被钙调蛋白抑制；其他三种亚型不磷酸化视紫红质，也不与钙调蛋白相互作用。GRK4-alpha和GRK4-gamma磷酸化DRD3。磷酸化ADRB2。 {ECO:0000269|PubMed:19520868, ECO:0000269|PubMed:8626439}。
组织特异性
Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.
亚细胞定位
Cytoplasm. Cytoplasm, cell cortex. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.
关键词