GPR61 Q9BZJ8

G蛋白偶联受体61 (生物胺受体样G蛋白偶联受体)

功能描述

孤儿G蛋白偶联受体。组成型激活G(s)-alpha/cAMP信号通路(PubMed:28827538)。与褪黑素受体MTNR1B表现出相互调节作用，最可能是通过受体异源二聚化实现(PubMed:28827538)。可能参与食物摄入和体重的调节(By similarity)。 {ECO:0000250|UniProtKB:Q8C010, ECO:0000269|PubMed:28827538}。

组织特异性

Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).

亚细胞定位

Cell membrane