GPR173 Q9NS66

可能的G蛋白偶联受体173 (脑表达超保守受体3)

功能描述

是SMIM20衍生肽Phoenixin-14和Phoenixin-20的受体 (By similarity)。它介导下丘脑和垂体中Phoenixin-14和Phoenixin-20增强的促性腺激素释放激素(GNRH)信号传导 (By similarity)。在卵巢中，它介导Phoenixin-14和Phoenixin-20诱导的卵泡生长期间颗粒细胞增殖作用 (PubMed:30933929)。 {ECO:0000250|UniProtKB:Q9JJH2, ECO:0000269|PubMed:30933929}。

组织特异性

Expressed in the ovary, specifically in granulosa cells of follicles that have passed the primary stage and in oocytes (at protein level) (PubMed:30933929). Expressed at high levels in brain. Lower levels in small intestine. In brain regions, detected in all regions tested. Highest levels in the cerebellum and cerebral cortex.

亚细胞定位

Cell membrane