GPR15LG Q6UWK7

GPR15LG蛋白 (具有57个氨基酸残基的抗菌肽) (AP-57) (抗菌肽-57) (结肠源性SUSD2结合因子) (CSBF) (GPR15配体蛋白) (GPR15L蛋白) (分泌蛋白C10orf99)

功能描述

高阳离子protein，具有多种功能。作为趋化因子，通过结合并激活G-protein coupled receptor GPR15介导淋巴细胞向上皮募集 (PubMed:28900043, PubMed:28936214)。可能是一种肿瘤抑制因子；与SUSD2一起对结肠癌细胞具有生长抑制作用，包括G1细胞周期停滞 (PubMed:25351403)。可能调节角质形成细胞增殖 (PubMed:29872130)。此外，通过激活Mas-related G protein-coupled receptors (MRGPRs)，通过激活瘙痒选择性感觉神经元和肥大细胞脱颗粒参与致痒作用 (PubMed:35704588)。 {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:28936214, ECO:0000269|PubMed:29872130, ECO:0000269|PubMed:35704588}.; FUNCTION: 对革兰氏阳性菌（包括Staphylococcus aureus和Actinomyces spec.）、Mycoplasma hominis和慢病毒具有抗菌活性 (PubMed:25585381)。 {ECO:0000269|PubMed:25585381}.

组织特异性

Expressed at high levels in colon, and cervix and at moderate level in tonsil (PubMed:25585381, PubMed:28900043). Highly reduced expression in primary colon cancer tissues compared with that in adjacent tissues (PubMed:25351403). Highest levels of expression detected in stomach and colon; expressed in epithelium of skin and esophagus, and in some tumor and/or tumor adjacent tissues (TAT), including TAT of esophagus cancer, hepatocellular carcinoma (HCC), squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and invasive ductal carcinoma (IDC) tissues (at protein level) (PubMed:25585381). Highly expressed by inflammatory differentiated keratinocytese (PubMed:35704588).

亚细胞定位

Secreted