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GPR156 Q8NFN8

推测G蛋白偶联受体156 (G蛋白偶联受体PGR28) (GABAB相关G蛋白偶联受体)

蛋白质信息 (UniProt)

推测G蛋白偶联受体156 (G蛋白偶联受体PGR28) (GABAB相关G蛋白偶联受体)

Q8NFN8

功能描述

孤儿G蛋白偶联受体,参与内耳机械感觉器官中毛细胞定向的调节。它是触发毛细胞定向180度逆转所必需的,从而产生一条虚拟的极性逆转线(LPR),静纤毛束在两侧以相反的方向排列。 {ECO:0000250|UniProtKB:Q6PCP7}。

组织特异性

Ubiquitous expression both in the CNS and in peripheral tissues. Very high expression in fetal brain and testis relative to expression in other tissues.

亚细胞定位

Cell membrane; Multi-pass membrane protein.

关键词

3D-structure Alternative splicing Cell membrane Coiled coil Deafness Disease variant G-protein coupled receptor Glycoprotein Membrane Non-syndromic deafness