GPHB5 Q86YW7

糖蛋白激素β-5 (促甲状腺素亚基β)

功能描述

作为与GPHA2形成的异源二聚体糖蛋白激素发挥作用，能够结合并激活促甲状腺激素受体(TSHR)，导致cAMP产生增加。在控制甲状腺细胞代谢中发挥核心作用。{ECO:0000269|PubMed:12045258, ECO:0000269|PubMed:16210345}。

组织特异性

Highly expressed in brain and at low levels in pituitary. Also found in retina, testis and skin but not in pancreas, parotid, kidney, stomach, liver, colon, small intestine, thyroid, brain or adrenal gland. In pituitary, colocalizes with ACTH, suggesting that it is located in corticotrophs.

亚细胞定位

Secreted.