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GPAA1 O43292

GPI锚定转酰胺酶成分GPAA1 (GAA1蛋白同源物) (hGAA1) (糖基磷脂酰肌醇锚定附着蛋白1) (GPI锚定附着蛋白1)

蛋白质信息 (UniProt)

GPI锚定转酰胺酶成分GPAA1 (GAA1蛋白同源物) (hGAA1) (糖基磷脂酰肌醇锚定附着蛋白1) (GPI锚定附着蛋白1)

O43292

功能描述

糖基磷脂酰肌醇锚(GPI-anchor)转酰胺酶(GPI-T)复合物的组分,催化前体蛋白与GPI-anchor之间连接的形成,并参与GPI锚定蛋白的生物合成(PubMed:11483512, PubMed:29100095, PubMed:34576938, PubMed:35165458, PubMed:35551457, PubMed:37684232, PubMed:9468317)。结合GPI-anchor(PubMed:37684232)。 {ECO:0000269|PubMed:11483512, ECO:0000269|PubMed:29100095, ECO:0000269|PubMed:34576938, ECO:0000269|PubMed:35165458, ECO:0000269|PubMed:35551457, ECO:0000269|PubMed:37684232, ECO:0000269|PubMed:9468317}。

组织特异性

Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues.

亚细胞定位

Endoplasmic reticulum membrane

关键词

3D-structure Alternative splicing Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein GPI-anchor biosynthesis Membrane Proteomics identification