鸟苷酸结合蛋白亚基α-13 (G alpha-13) (G蛋白亚基α-13)
鸟苷酸结合蛋白亚基α-13 (G alpha-13) (G蛋白亚基α-13)
Q14344功能描述
鸟嘌呤核苷酸结合蛋白（G蛋白）作为调节因子或转换器参与各种跨膜信号系统 (PubMed:15240885, PubMed:16705036, PubMed:16787920, PubMed:27084452)。通过结合并激活RhoGEFs（ARHGEF1/p115RhoGEF、ARHGEF11/PDZ-RhoGEF和ARHGEF12/LARG）激活效应分子RhoA (PubMed:12515866, PubMed:15240885)。依赖GNA13的Rho信号随后调节转录因子AP-1（激活蛋白-1） (By similarity)。通过激活RhoA/ROCK信号通路促进肿瘤细胞侵袭和转移 (PubMed:16705036, PubMed:16787920, PubMed:27084452)。在不依赖Rho激活的过程中抑制CDH1介导的细胞粘附 (PubMed:11976333)。在淋巴滤泡中，传递依赖P2RY8和S1PR2的信号，导致抑制生发中心（GC）B细胞的生长及向GC生态位外的迁移。 {ECO:0000250|UniProtKB:P27601, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:27084452}。
组织特异性
Expressed in testis, including in Leydig cells and in the seminiferous epithelium, in differentiating cells from the spermatogonia to mature spermatozoa stages and round spermatids (at protein level). Expressed in 99.2% of spermatozoa from healthy individuals, but only in 28.6% of macrocephalic spermatozoa from infertile patients (at protein level).
亚细胞定位
Cell membrane
关键词